Faculty Research Profile
Eunhee Kim
학력
• 2007: Ph.D. Ajou University School of Medicine
• 2004: M.S. Ajou University School of Medicine
• 2002: B.S. Ajou University
주요 경력
• 2023~present: Associate Professor Ulsan National Institute Science and Technology (UNIST)
• 2016~2022: Assistant Professor, Ulsan National Institute Science and Technology (UNIST)
• 2013~2016: Research Associate, Memorial Sloan Kettering Cancer Center, New York, USA
• 2009~2013: Postdoctoral fellow, Cleveland Clinic, Cleveland, USA
• 2007~2009: Postdoctoral fellow, Ajou University School of Medicine
수상/학회/외부활동
• 2015~2016: Worldwide Cancer Research Grant
• 2014. 12: ASH Abstract Achievement Award
• 2013. 08: FASEB Science Research Conference Poster Award
• Member of American Association for Cancer Research
• Member of Korean Society for Molecular and Cellular Biology
• Member of Korean Society for Cell Biology
• Member of Korean Society for Biochemistry and Molecular Biology
Member of Korean Cancer Association
분자종양학 연구실
Molecular Oncology Laboratory
저희 연구실은 암 생물학에 대한 이해를 심화시켜, 암의 예방 및 치료에 활용될 수 있는 혁신적인 치료 전략을 개발하는 것을 목표로 하고 있습니다.
이를 위해 기초 암 생물학 연구와 치료 응용 전략을 통합적으로 수행하며, 암 특이적 변이의 기능적 결과를 분석하고, 치료 가능한 약점(vulnerability)을 발굴하는 연구를 진행하고 있습니다.
주요 연구 분야
• 암 발생의 분자적 기전 규명 - 암의 시작과 진행 과정에서 나타나는 세포 및 분자 수준의 변화, 특히 비정상적인 신호전달과 유전적 변이 연구
• 암 관련 신호전달 경로 및 치료 표적 발굴 - 암세포의 생존과 증식에 핵심적인 역할을 하는 신호 네트워크를 규명하고, 이를 기반으로 치료 가능한 새로운 분자 표적 탐색
• 암세포 선택적 사멸을 유도하는 치료 전략 개발 - 정상세포에는 영향을 최소화하면서 암세포를 선택적으로 제거할 수 있는 표적 치료 전략을 제안하고, 치료 효과 검증
* 저희 연구실은 암의 근본적인 병태생리를 이해하는 기초연구와 이를 기반으로 한 정밀의학적 치료 전략 개발 간의 연결고리를 마련함으로써, 차세대 항암 치료법 개발에 기여하고자 합니다.
Our lab’s research goal is to promote our understanding of cancer with the aim of developing novel therapeutics that can be used as preventive and/or curative therapy. To this end, we are focusing on understanding the functional impact of genetic alterations in cancer and suggesting an attractive strategy for safely treating cancer.
Our current research interests are:
•Understanding the molecular mechanisms of cancer development
•Identification of signaling pathways and molecular targets involved in cancers
•Study on the therapeutic strategies to selectively kill cancer cells
Our lab’s research goal is to promote our understanding of cancer with the aim of developing novel therapeutics that can be used as preventive and/or curative therapy. To this end, we are focusing on understanding the functional impact of genetic alterations in cancer and suggesting an attractive strategy for safely treating cancer.
Our current research interests are:
•Understanding the molecular mechanisms of cancer development
•Identification of signaling pathways and molecular targets involved in cancers
•Study on the therapeutic strategies to selectively kill cancer cells
연구분야
암생물학, 세포생물학_소기관 스트레스, 분자생물학_RNA 스플라이싱 / Cancer Biology, Cell Biology_Organelle stress, Molecular Biology_RNA Splicing
Cancer Biology, Cell Biology_Organelle stress, Molecular Biology_RNA Splicing
연구 희망분야
세포사멸기전, 암제어 전략 / Cell Death Mechanisms, Anticancer therapeutic strategies
Cell Death Mechanisms, Anticancer therapeutic strategies
연구주제
• 암 발생의 분자 기전 이해
Understanding the molecular mechanisms of cancer development
• 암과 관련된 신호전달경로 및 분자 표적 규명
Identification of signaling pathways and molecular targets involved in cancers
• 암세포 선택적 사멸 유도 전략 연구
Study on the therapeutic strategies to selectively kill cancer cells
• Understanding the molecular mechanisms of cancer development
• Identification of signaling pathways and molecular targets involved in cancers
• Study on the therapeutic strategies to selectively kill cancer cells
국가연구개발사업 기술 분류체계
국가과학기술표준분류
LA. 생명과학 > LA01. 분자세포생물학 > LA0199. 달리 분류되지 않는 분자세포 생물학
논문
• Cell Death Discovery, Dual role of p21 in regulating apoptosis and mitotic integrity in response to doxorubicin in colon cancer cells. Kim H, Kim H, Jang E, Eom E-W, Yoon G, Choi KS, Kim E* (202504)
• Nano Today, CD13-targeting and TRAIL-displaying protein nanoparticles effectively induce apoptotic cell death of acute myeloid leukemia, prolonging survival in mouse models. Jun H, Yeo M, Jeon JP, Eom S, Kim HJ, Kim Y, Jang E, Park SH*, Kim E*, Kang S* (202412)
• Cell Death and Disease, Akt enhances the vulnerability of cancer cells to VCP/p97 inhibition-mediated paraptosis. Lee DM, Kim IY, Lee HJ, Seo MJ, Cho, M-Y, Lee HI, Yoon G, Ji, J-H, Park SS, Jeong, S-Y, Choi EK, Choi YH, Yun C-O, Yeo M, Kim E*, Choi KS* (202401)