Faculty Research Profile

의과학대학원

최승원

조교수Seung-Won Choi

최승원

Seung-Won Choi

Biography

학력

2019 PhD. Health Science and Technology, SAIHST

2014 MS, Ulsan University School of Medicine

2009 MD, Ewha Womans University School of Medicine

주요 경력

2025~present: Assistant Professor, Graduate School of Health Science and Technology, UNIST
2021-2025 : Postdoctoral Research Fellow, Systems Biology, Columbia University
2019-2021 : Clinical Fellow, Dept. of Neurosurgery, Ssamsung Medical Center
2025 : Clinical Fellow, Pediatric Neurosurgery, Asan Medical Center
2010-2014 : Resident, Dept. of Neurosurgery, Asan Medical Center

Research

신경종양 정밀의학 연구실

Neuro-Oncology Precision Medicine Lab

뇌종양은 뇌라는 장기의 특수성으로 인해 다른 암종에 비해 치료 방법이 제한적입니다. 특히 신경교종은 현대 의학의 발전에도 불구하고 치료 성과가 미비한 대표적인 난치성 암입니다.본 연구실은 환자의 임상 데이터와 다중 오믹스 데이터를 통합적으로 분석하여 뇌종양의 치료 저항성의 원인과 기전을 규명하고, 환자 맞춤형 치료 전략을 제시하는 것을 목표로 하고 있습니다. 특히 신경교종의 유전적 다양성과 종양 미세환경과의 상호작용을 중점적으로 연구하여, 궁극적으로 환자에게 최적화된 치료법을 찾고자 합니다.
Brain tumors pose unique therapeutic challenges due to the special characteristics of the brain. Among them, gliomas—the most common primary malignant brain tumors—remain among the most devastating cancers, with limited treatment options despite recent advances in medicine. Our laboratory integrates clinical and multi-omics data to elucidate the biological mechanisms underlying treatment resistance and to identify novel therapeutic vulnerabilities. Given the pronounced heterogeneity of gliomas, we focus on developing individualized precision medicine strategies and dissecting cellular interactions within the tumor microenvironment. Ultimately, our goal is to translate these insights into improved outcomes and better lives for patients with brain tumors.

Brain tumors pose unique therapeutic challenges due to the special characteristics of the brain. Among them, gliomas—the most common primary malignant brain tumors—remain among the most devastating cancers, with limited treatment options despite recent advances in medicine. Our laboratory integrates clinical and multi-omics data to elucidate the biological mechanisms underlying treatment resistance and to identify novel therapeutic vulnerabilities. Given the pronounced heterogeneity of gliomas, we focus on developing individualized precision medicine strategies and dissecting cellular interactions within the tumor microenvironment. Ultimately, our goal is to translate these insights into improved outcomes and better lives for patients with brain tumors.

신경종양 정밀의학 연구실

연구분야

신경종양학 정밀의학, 신경교종 종양미세환경, 난치성 종양의 약물유전체 연구

Precision medicine in neuro-oncology, Tumor microenvironment in gliomas, Pharmacogenomic study in refractory malignancies

연구주제

뇌종양, 뇌교종, 정밀의료, 종양미세환경, 약물유전체학, 시스템바이올로지
brain tumor, glioma, neuro-oncology, tumor microenvironment, pharmacogenomics, systems biology

brain tumor, glioma, neuro-oncology, tumor microenvironment, pharmacogenomics, systems biology

국가연구개발사업 기술 분류체계

국가과학기술표준분류

LC. 보건의료 > LC01. 의생명과학 > LC0111. 오믹스학

Outputs

논문

1. Cancer Medicine, “A Multicenter, phase II trial of GC1118, a novel anti-EGFR antibody, for recurrent glioblastoma patients with EGFR amplification”, Choi SW et al, 2023
2. Cell Death & Disease, “Mutation-specific non-canonical pathway of PTEN as a distinct therapeutic target for glioblastoma”, Choi SW et al, 2021
3. Cancers, "Multi-habitat radiomics unravels distinct phenotypic subtypes of glioblastoma with clinical and genomic significance", Choi SW et al, 2020