Faculty Research Profile
Sangjoon Lee
학력
· 2018: Ph.D. Human Biology, University of Tsukuba
· 2013: B.S. Biomedical Laboratory Science, Inje University
주요 경력
· 2022-Present: Assistant Professor, UNIST
· 2020-2022: Postdoctoral Associate, Department of Immunology, St. Jude Children’s Research Hospital, USA
· 2018-2020: Postdoctoral Associate, Department of Infection Biology, University of Tsukuba, Japan
수상/학회/외부활동
· 2025: KDDF Grant (국가신약개발사업)
· 2025: Korea NIH Grants
(질병관리청 국립보건원)
· 2023: The Circle Foundation Award
(동그라미 재단)
· 2022: Yuhan Innovation Fellowship
(유한양행)
· 2022: Young Scientist Research Grant
(한국연구재단)
바이러스 면역학 연구실
Viral Immunology Lab
우리는 바이러스 감염 시 숙주의 선천면역 시스템이 이를 어떻게 감지하고 염증성 세포사멸로 숙주의 운명을 결정하는지를 연구합니다. 우리는 전장 CRISPR 노크아웃 스크리닝과 다양한 선천면역 센서 KO 마우스 라이브러리를 활용하여 새로운 면역 센서를 규명하고, PANoptosis와 같은 염증성 세포사멸 기전을 밝힙니다. 이러한 기전을 기반으로, 우리는 선천면역 경로를 표적으로 하는 차세대 치료제 개발을 목표로 합니다.
We study how the host innate immune system detects viral infections and determines host fate through inflammatory cell death pathways. Utilizing genome-wide CRISPR knockout screening and innate immune sensor KO mouse libraries, we identify novel sensors and dissect pathways such as PANoptosis. By translating these insights, we aim to develop next-generation therapeutics targeting innate immune pathways.
We study how the host innate immune system detects viral infections and determines host fate through inflammatory cell death pathways. Utilizing genome-wide CRISPR knockout screening and innate immune sensor KO mouse libraries, we identify novel sensors and dissect pathways such as PANoptosis. By translating these insights, we aim to develop next-generation therapeutics targeting innate immune pathways.
연구분야
Innate Immunity, Virology, Infection Biology, Cell death Biology
Innate Immunity, Virology, Infection Biology, Cell death Biology
연구 희망분야
Antiviral Drug Discovery, Vaccine Development
Antiviral Drug Discovery, Vaccine Development
연구주제
Virus, Innate immunity, Cell death, Inflammasome, Inflammation, PANoptosis
Virus, Innate immunity, Cell death, Inflammasome, Inflammation, PANoptosis
국가연구개발사업 기술 분류체계
국가과학기술표준분류
LA. 생명과학 > LA04. 면역학·생리학 > LA0402. 선천성 면역
논문
1. Herpes simplex virus1 harboring poly(T) DNA sequences as a key ligand for AIM2 inflammasome activation and host defense
Nature communications (IF: 17) (2026)
2. Innate immune sensing of dietary alcohol ignites inflammation to drive alcohol-related disease.
Science Advances (IF: 12) (2026)
3. AIM2 drives inflammatory cell death and monkeypox pathogenesis
Cellular & Molecular Immunology (IF: 22) (2025)
4. Integrated NLRP3, AIM2, NLRC4, Pyrin inflammasome activation and assembly drive PANoptosis
Cellular & Molecular Immunology (IF: 22) (2023)
5. ZBP1-dependent inflammatory cell death, PANoptosis, and cytokine storm disrupt IFN therapeutic efficacy during coronavirus infection
Science Immunology (IF: 17) (2022)
6. AIM2 forms a complex with Pyrin and ZBP1 to drive PANoptosis and host defense
Nature (IF: 48) (2021)
7. Influenza restriction factor MxA functions as inflammasome sensor in the respiratory epithelium
Science Immunology (IF: 17) (2019)