연구처

유전체 손상 반응 및 독성물

DNA Damage Response and Genetic Toxicology

“유전체 손상 반응 및 독성물” 연구실은 돌연변이 유발의 기본 메커니즘과 정확한 게놈 유지를 보장하고 프로그래밍 된 세모 사멸로 손상된 세포를 제거하는 안전 메커니즘을 연구하고 있습니다. 우리는 C. elegans를 무척추 동물 모델로 사용하고 고급 유전학, 유전체학, 세포 생물학 및 차세대 시퀀싱 기반 접근 방식을 사용합니다. 단순함에도 불구하고 C. elegans는 인간과 많은 기본 유전 프로그램을 공유하는 다세포 유기체입니다. 따라서 C. elegans 시스템에서 얻은 많은 결과는 포유류 시스템에 적용할 수 있습니다. C. elegans에 대한 우리의 연구는 발달 및 해부학적 수준에서 유기체의 단순성, 유지 관리의 용이함, 전진 및 역 유전 절차의 힘에 의해 촉진됩니다. 우리의 연구는 암 형성으로 이어지는 근본적인 메커니즘을 이해하는 것과 관련이 있으며 암 치료에 일반적으로 사용되는 다양한 약제를 더 잘 이해하고 더 효과적으로 사용하는 것을 목표로 합니다.
Our research focuses on understanding the basic mechanisms of mutagenesis and on fail-safe mechanisms that ensure faithful genome maintenance and the elimination of compromised cells by programmed cell death. We mainly use C. elegans as an invertebrate model organism and employ advanced genetics, genomics, cell biology, and next-generation sequencing-based approaches. Despite its simplicity, C. elegans is a multicellular organism that shares many fundamental genetic programs with humans. Thus, many results obtained in the C. elegans system are likely to be applicable to mammalian systems. Our studies on C. elegans are facilitated by the simplicity of the organism at the developmental and anatomical level, by the ease of its maintenance, as well as by the power of forward and reverse genetic procedures. At the same time, we use mammalian cells to translate our insights gained from the invertebrate model. Our studies are relevant for understanding fundamental mechanisms leading to cancer formation and also aimed to better understand and more effectively use a range of agents commonly used for cancer therapy. We are engaged in multiple national and international collaborations.

Our research focuses on understanding the basic mechanisms of mutagenesis and on fail-safe mechanisms that ensure faithful genome maintenance and the elimination of compromised cells by programmed cell death. We mainly use C. elegans as an invertebrate model organism and employ advanced genetics, genomics, cell biology, and next-generation sequencing-based approaches. Despite its simplicity, C. elegans is a multicellular organism that shares many fundamental genetic programs with humans. Thus, many results obtained in the C. elegans system are likely to be applicable to mammalian systems. Our studies on C. elegans are facilitated by the simplicity of the organism at the developmental and anatomical level, by the ease of its maintenance, as well as by the power of forward and reverse genetic procedures. At the same time, we use mammalian cells to translate our insights gained from the invertebrate model. Our studies are relevant for understanding fundamental mechanisms leading to cancer formation and also aimed to better understand and more effectively use a range of agents commonly used for cancer therapy. We are engaged in multiple national and international collaborations.