Faculty Research Profile
Jiyoung Park
학력
· 2005: Ph.D Seoul National University
· 2001: MS. Seoul National University
· 1999: BS. Ewha Womans University
주요 경력
· 2024~present: Ulsan National Institute of Science and Technology, Professor
· 2019~2024: Ulsan National Institute of Science and Technology, Associate Professor
· 2014~2019: Ulsan National Institute of Science and Technology, Assistant Professor
· 2011~2013: University of Texas Southwestern Medical Center, Dallas, USA, Instructor
· 2007~2011: University of Texas Southwestern Medical Center, Dallas, USA, Post-doctoral fellow
· 2005~2007: Seoul National University, Post-doctoral fellow
수상/학회/외부활동
· 2024.04: 2023 UNIST Outstanding Faculty Awards
· 2023.11: Award for Women in Life Science (KSMCB)
· 2019~present: Women’s Bioscience Forum
· 2014~present: Korean Society of Biochemical and Molecular Biology
· 2010~present: American Association of Cancer Research
· 2010~present: American Diabetes Association
· 2010~present: Korean Society for Molecular and Cellular Biology
분자대사학연구실
Molecular Metabolism Laboratory
비만 연관 당뇨 및 암 질환의 분자 기전을 밝히고 치료제 개발을 위한 연구를 진행하고 있습니다.
· 세포외 기질단백질에 의한 지방조직 리모델링 연구
· 지방조직 분비체 기반 대사성 질환 치료제 개발 연구
· 종양미세환경에서 지방세포와 암세포간의 상호신호 전달계 연구
· 대사스트레스에 의한 암세포 대응기전 연구
Our research group is mainly focusing on the adipocyte biology at the level of metabolism and cancer. Through underlying the molecular mechanisms of obesity-related metabolic diseases, we aim to develop novel therapeutics for the metabolism and cancers. Main research topics are listed in below;
· Adipose tissue remodeling via modulation of extracellular matrix proteins
· Development of adipokine-based therapeutics for obesity-related metabolic diseases
· Underlying the signaling networks between stromal adipocytes and cancer cells within the tumor microenvironment
· Underlying the molecular mechanisms of metabolic stress-induced alteration of cancer cell behaviors
Our research group is mainly focusing on the adipocyte biology at the level of metabolism and cancer. Through underlying the molecular mechanisms of obesity-related metabolic diseases, we aim to develop novel therapeutics for the metabolism and cancers. Main research topics are listed in below;
· Adipose tissue remodeling via modulation of extracellular matrix proteins
· Development of adipokine-based therapeutics for obesity-related metabolic diseases
· Underlying the signaling networks between stromal adipocytes and cancer cells within the tumor microenvironment
· Underlying the molecular mechanisms of metabolic stress-induced alteration of cancer cell behaviors
연구분야
Adipocyte, Obesity, Diabetes, Cancers, Therapeutics
Adipocyte, Obesity, Diabetes, Cancers, Therapeutics
연구 희망분야
ECM and fibrotic diseases
ECM and fibrotic diseases
연구주제
· Obesity-related metabolic diseases and cancers
· Adipose tissue remodeling
· Extracellular matrix protein (ECM) and fibrosis
· Obesity-related metabolic diseases and cancers
· Adipose tissue remodeling
· Extracellular matrix protein (ECM) and fibrosis
국가연구개발사업 기술 분류체계
국가과학기술표준분류
LA. 생명과학 > LA01. 분자세포생물학 > LA0103. 세포분화/사멸
논문
· Cancer Research. FAM3C in cancer-associated adipocytes promotes breast cancer cell survival and metastasis. Kim S, Oh J, Park C, Kim M, Jo W, Kim C-S, Cho SW and Park J*. (IF: 16. 6) 2024.01. 84 (4): 545–559
· Metabolism-Clinical and Experimental. High levels of intracellular endotrophin in adipocytes mediate COPII vesicle supplies to autophagosome to impair autophagic flux and contribute to systemic insulin resistance in obesity. Oh J, Park C, Kim S, Kim M, Kim C-S, Jo W, Park S, Yi G-S, and Park J*. (145) 155629 (IF: 13. 934) 2023.08
· Nature Communications. Epigenetic regulation of Neuregulin 1 promotes breast cancer progression associated to hyperglycemia. Lee C, Kim M, Park C, Jo W, Seo JK, Kim S, Oh J, Kim C-S, Ryu HS, Lee K-H and Park J*. 14(1) 439 (IF: 17. 694) 2023.02
특허
· [국내] 엔도트로핀 절단 효소의 저해제를 포함하는 엔도트로핀 활성 저해용 조성물 및 이의 용도. 박지영, 김민, 이상민, 조우빈. 2020.02.03 (대한민국)
· [국외] Endotrophin neutralization and use thereof. Philipp.E. Scherer, Jiyoung Park, Zhiqiang An. 2017.03.28 (USA Patent)