Faculty Research Profile
Yong Hwan Kim
학력
• 1996: Ph.D. Chemical Engineering, Seoul National University
• 1993: M.S. Chemical Engineering, Seoul National University
• 1991: B.S. Chemical Engineering, Seoul National University
주요 경력
• 2024 - Present: Dean of The college of Engineering, UNIST
• 2016 - Present: Full Professor, UNIST
• 2010 - 2016: Full Professor, Kwangwoon University
수상/학회/외부활동
• 2025: The National Academy of Engineering of Korea Member (NAEK)
• 2022: National Excellent Climate Mitigation Award 10
• 2018: National Excellent Research Award 100
• 2015: Best Research Award of Kwangwoon University
• 2015: Best Project Award of Kwangwoon University
• 2014: BBE Journal Award (KSBB)
• 2014: Best Paper Award (KOFST)
• 2011: Best Project Award of Kwangwoon University
효소단백질공학연구실
Enzyme and Protein Engineering Lab
Enzyme, a kind of specialized protein is biocatalyst to accelerate the reaction in living Biosystems by reducing the required activation energy barrier. Without enzymes, any cellular Biosystems cannot sustain its life system anymore. The acceleration of reaction and specificity of enzymes seems almost miracle since reaction rate can be increased up to billion times higher. Nowadays enzymes can be applied for not only living Biosystems but also chemical industries. Very mild reaction conditions such as room temperature, aqueous phase is enough for the synthesis of many kinds of value-added compounds such as pharmaceuticals, cosmetic ingredients and even bulk chemicals by employing enzymes as biocatalysts. However, even though enzymes seem miracle-like, its stability and reaction characteristics may be not optimized to be utilized for the chemical process. Our lab is actively trying to engineer these enzymes to be more optimized and superior biocatalysts capable of converting raw material to value-added compounds through rational and 3D structure-based design of biocatalysts.
Enzyme, a kind of specialized protein is biocatalyst to accelerate the reaction in living Biosystems by reducing the required activation energy barrier. Without enzymes, any cellular Biosystems cannot sustain its life system anymore. The acceleration of reaction and specificity of enzymes seems almost miracle since reaction rate can be increased up to billion times higher. Nowadays enzymes can be applied for not only living Biosystems but also chemical industries. Very mild reaction conditions such as room temperature, aqueous phase is enough for the synthesis of many kinds of value-added compounds such as pharmaceuticals, cosmetic ingredients and even bulk chemicals by employing enzymes as biocatalysts. However, even though enzymes seem miracle-like, its stability and reaction characteristics may be not optimized to be utilized for the chemical process. Our lab is actively trying to engineer these enzymes to be more optimized and superior biocatalysts capable of converting raw material to value-added compounds through rational and 3D structure-based design of biocatalysts.
연구분야
C1 gas conversion, Lignin conversion, Cosmetics application
C1 gas conversion, Lignin conversion, Cosmetics application
연구 희망분야
Enzyme sequence and function relationship, How to increase activity of enzyme?
Enzyme sequence and function relationship, How to increase activity of enzyme?
연구주제
• 구조기반 효소 재설계
• CO2, CO 전환 효소 재설계 및 효소 이용 공정 설계
• 리그닌 분해효소 재설계 및 효소 이용 리그닌 분해 공정 설계
• 효소 이용 화장품 원료 생산 기술 개발
• C1 gas (CO2, CO) enzymatic conversion Production of formate from CO and CO2 using enzymes
• Lignin refinery Lignin de-polymerization enzyme development and production of value added aromatics from lignin
• Application of enzymes for cosmetics Whitening cosmetics using melanin decolorizing enzyme
• C1 gas (CO2, CO) enzymatic conversion Production of formate from CO and CO2 using enzymes
• Lignin refinery Lignin de-polymerization enzyme development and production of value added aromatics from lignin
• Application of enzymes for cosmetics Whitening cosmetics using melanin decolorizing enzyme
국가연구개발사업 기술 분류체계
국가과학기술표준분류
EC. 화공 > EC04. 생물화학공정기술 > EC0403. 효소생물 공정기술
논문
- ANGEWANDTE CHEMIE, "Fortification of FeS Clusters Reshapes Anaerobic CO Dehydrogenase into an Air-Viable Enzyme Through Multilayered Sealing of O2 Tunnels", 202508
- ACS CATALYSIS, "Lignin Peroxidase-Catalyzed Selective Cleavage of C−C Bonds in Lignin at Room Temperature", 202408
- NATURE CHEMICAL ENGINEERING, "Molar-scale formate production via enzymatic hydration of industrial off-gases", 202405
- NATURE COMMUNICATIONS, "Identifying a key spot for electron mediator interaction to tailor CO dehydrogenase’s affinity", 202403
- NATURE CATALYSIS, "O2-tolerant CO dehydrogenase via tunnel redesign for the removal of CO from industrial flue gas", 202209
- NATURE COMMUNICATIONS, "Unassisted solar lignin valorisation using a compartmented photo-electro-biochemical cell", 201911
특허
• CO hydratase and method for producing formate using the same / Yong Hwan Kim / US Pat. 10,240,170 B2
• CO hydratase and method for producing formate using the same / Yong Hwan Kim / EU Pat. 17,722,365.8