Faculty Research Profile
Duyoung Min
학력
• Ph.D., Biophysics, Department of Physics, KAIST
• B.S., Electrical Engineering and Computer Science, Hanyang University
주요 경력
• Associate Professor, Department of Chemistry, UNIST
• Assistant Professor, Department of Chemistry, UNIST
• Postdoctoral Fellow, Department of Chemistry and Biochemistry, UCLA
• Postdoctoral Fellow, Department of Physics, KAIST
수상/학회/외부활동
• CNS CONNECT Award for Outstanding Collaborative Research, UNIST (2025)
• UCLA Chancellor’s Award for Postdoctoral Research, UCLA (2018)
• Postdoctoral Research Award, Dept. of Chemistry and Biochemistry, UCLA (2018)
• Postdoctoral Overseas Training Grant, National Research Foundation of Korea (2016)
• Dean’s Prize Award for the Valedictorian of the College of Engineering, Hanyang University (2008)
나노 바이오 동역학 연구실
Nano Bio Dynamics Laboratory
생체막 단백질(이하, 막단백질)은 세포 간 신호전달, 면역반응, 대사물질 교환 등에 관여하며, 상용화된 약물 분자들의 주요 표적 단백질입니다. 본 연구실에서는 주로 단일분자 측정기술과 분자동역학 시뮬레이션 기법을 활용하여 숨겨진 막단백질의 구조 동역학을 연구하고 있으며, 이는 보다 효과적인 약물 개발에 기여할 수 있습니다. 특히, 막단백질이 어떻게 3차원적 구조를 형성하고 기능하는지, 다른 단백질 및 생체 분자들과 어떻게 상호작용하는지 이해하고자 노력하고 있습니다. 또한, 최근에는 질병 및 노화와 관련된 단백질 산화 손상 및 생명정보학 분야로 연구 범위를 확장하고 있습니다.
Membrane proteins play key roles in human health, contributing to cellular signaling, immunity, and material exchange. Additionally, this class of proteins is a major target for commercial drug molecules. We are therefore dedicated to unveiling their hidden dynamics using single-molecule tools and molecular dynamics simulation, which could contribute to the development of effective therapeutic interventions. Specifically, our focus is on understanding how membrane proteins fold into their native structures and how they interact with other proteins and biomolecules. We are also expanding our research scope to include fields such as protein oxidative damage and proteomics.
Membrane proteins play key roles in human health, contributing to cellular signaling, immunity, and material exchange. Additionally, this class of proteins is a major target for commercial drug molecules. We are therefore dedicated to unveiling their hidden dynamics using single-molecule tools and molecular dynamics simulation, which could contribute to the development of effective therapeutic interventions. Specifically, our focus is on understanding how membrane proteins fold into their native structures and how they interact with other proteins and biomolecules. We are also expanding our research scope to include fields such as protein oxidative damage and proteomics.
연구분야
막단백질 접힘, 단백질 상호작용, 단분자 측정기술, 분자동역학 시뮬레이션 / Membrane protein folding, Protein-protein interaction, Single-molecule methods, MD simulation
Membrane protein folding, Protein-protein interaction, Single-molecule methods, Molecular dynamics simulation
연구 희망분야
막단백질 접힘, 단백질 상호작용, 단분자 측정기술, 분자동역학 시뮬레이션 / Membrane protein folding, Protein-protein interaction, Single-molecule methods, MD simulation
Membrane protein folding, Protein-protein interaction, Single-molecule methods, Molecular dynamics simulation
연구주제
막단백질 접힘, 단백질-단백질 상호작용, 단백질 산화 손상, 단분자 측정기술 개발, 분자동역학 시뮬레이션
Membrane protein folding, Protein-protein interaction, Oxidative protein damage, Single-molecule tools and development, Molecular dynamics simulation
Membrane protein folding, Protein-protein interaction, Oxidative protein damage, Single-molecule tools and development, Molecular dynamics simulation
국가연구개발사업 기술 분류체계
국가과학기술표준분류
NC. 화학 > NC01. 물리화학 > NC0107. 생물리화학
논문
• Nature Communications, Single-molecule tweezers decode hidden dimerization patterns of membrane proteins within lipid bilayers (2025)
• Nano Today, Compact clustering of highly oligomerized anti-DR5 nanobodies effectively drives apoptotic cancer cell death...(2025)
• Nature Communications, Hidden route of protein damage through oxygen-confined photooxidation (2024)
• Advanced Science, Rational design of biocompatible Ir(III) photosensitizer to overcome drug-resistant cancer...(2024)
• Nature Communications, Oxidative photocatalysis on membranes triggers non-canonical pyroptosis (2024)
• eLife, Robust membrane protein tweezers reveal the folding speed limit of helical membrane proteins (2023)