Faculty Research Profile
Jae Ick Kim
학력
· 2005.3~2012.2: Ph.D. (Neurobiology), Department of Biological Sciences, Seoul National University, Korea
· 1997.3~2005.2: B.S., Department of Electrical Engineering, Seoul National University, Korea / B.S., Department of Biological Sciences, Seoul National University, Korea
주요 경력
· 2021.3~: Associate Professor, Department of Biological Sciences, UNIST, Korea
· 2017.2~: Assistant Professor, School of Life Sciences, UNIST, Korea
· 2013.3~2017.2: Postdoctoral fellow, Department of Neurosurgery, Stanford University, US
· 2012.3~2013.2: Postdoctoral fellow, Department of Biological Sciences, Seoul National University, Korea
수상/학회/외부활동
- Awards and Honors
· POSCO TJ Park Young Professor Fellowship (2018)
· Sammy Kuo Award (2nd place), Stanford Neuroscience Institute (2016)
· Basic Science Research Program Fellowship (2016)
· Brain Korea 21 Postdoctoral Fellowship (2012)
· Best Oral Presentation Award of 2011 KSBNS and MCCS-Asia Neuroscience Conference (2011)
· Seoul Science Fellowship (2006)
- Memberships
· Society for Neuroscience: member
· KSBNS: member
· KSBMB: member
· KSND: member
· AAAS: member
신경회로 및 퇴행성뇌질환 연구실
Neural Circuit and Neurodegenerative Disease Lab
기저핵은 선조체, globus pallidus, 시상하핵, 흑색질 등으로 이루어진 피질 하부의 거대한 뇌영역이다. 기저핵 시스템은 감각, 운동 정보를 종합하여 적절한 수의운동을 선택하고 조절하는 역할을 하며, 보상 및 동기 행동에도 광범위한 기능을 수행한다. 파킨슨병에서는 기저핵의 많은 영역들이 손상을 받는 것으로 알려져 있다. 본 연구실의 연구목표는 패치클램프 레코딩을 중심으로 한 전기생리학, 이광자 현미경법, 초고해상도 이미징, 광유전학, 동물행동분석 등의 다차원적인 실험기법들을 이용하여 다양한 복잡성 수준에서 존재하는 기저핵 신경회로의 기능을 밝히고, 보상, 동기, 운동학습과의 인과관계를 밝히는 것이다. 또한, 파킨슨병 등의 퇴행성 뇌질환들에서 나타나는 다양한 뇌영역들의 구조적, 기능적 이상을 규명하고, 파킨슨병의 증상이 나타나기 전 존재하는 생리학적 지표들을 발굴하고자 한다.
Basal ganglia are a group of subcortical nuclei including the striatum, globus pallidus, and substantia nigra. The major function of this system is to integrate both sensory and motor information, eventually leading to motor coordination, action selection, and reward-related learning, most of which are severely impaired in Parkinson’s disease. Our long-term goal is to identify the essential modification of basal ganglia circuitry contributing to the development of neurodegenerative diseases. Taking advantage of multi-disciplinary approaches including whole-cell patch clamp, single-unit recording, two-photon laser microscopy, super-resolution imaging, optogenetics, and behavioral assays, we also aim to identify pre-symptomatic physiological markers for Parkinson’s disease.
Basal ganglia are a group of subcortical nuclei including the striatum, globus pallidus, and substantia nigra. The major function of this system is to integrate both sensory and motor information, eventually leading to motor coordination, action selection, and reward-related learning, most of which are severely impaired in Parkinson’s disease. Our long-term goal is to identify the essential modification of basal ganglia circuitry contributing to the development of neurodegenerative diseases. Taking advantage of multi-disciplinary approaches including whole-cell patch clamp, single-unit recording, two-photon laser microscopy, super-resolution imaging, optogenetics, and behavioral assays, we also aim to identify pre-symptomatic physiological markers for Parkinson’s disease.
연구분야
Parkinson's disease, Alzheimer's disease, Basal ganglia microcircuits, Diffuse modulatory system, Dopamine neurons, Ageing
Parkinson's disease, Alzheimer's disease, Basal ganglia microcircuits, Diffuse modulatory system, Dopamine neurons, Ageing
연구 희망분야
Normal and pathological ageing, Developing an early diagnostic tool for Neurodegenerative diseases, Finding a cure for Parkinson's disease
Normal and pathological ageing, Developing an early diagnostic tool for Neurodegenerative diseases, Finding a cure for Parkinson's disease
연구주제
파킨슨병, 알츠하이머병, 퇴행성뇌질환, 기저핵 미세회로, 조절성 신경세포 시스템, 도파민 신경세포, 신경전달물질 동시전달, 정상 및 병적 노화, 퇴행성 뇌질환의 조기 진단법 개발, 파킨슨병의 치료기술 개발
Parkinson's disease, Alzheimer's disease, Neurodegenerative diseases, Basal ganglia microcircuits, Diffuse modulatory system, Dopamine neurons, Neurotransmitter co-transmission, Normal and pathological ageing, Developing an early diagnostic tool for neurodegenerative diseases, Finding a cure for Parkinson's disease
Parkinson's disease, Alzheimer's disease, Neurodegenerative diseases, Basal ganglia microcircuits, Diffuse modulatory system, Dopamine neurons, Neurotransmitter co-transmission, Normal and pathological ageing, Developing an early diagnostic tool for neurodegenerative diseases, Finding a cure for Parkinson's disease
국가연구개발사업 기술 분류체계
국가과학기술표준분류
OA. 뇌과학 > OA01. 뇌신경생물 > OA0103. 시냅스 및 신경신호전달
논문
· BMC Biology, mtIF3 is locally translated in axons and regulates mitochondrial translation for axonal growth, Lee S/Park D/Lim C/Kim JI/Min KT, (2022.01)
· Brain, O-GlcNAcylation regulates dopamine neuron function, survival, and degeneration in Parkinson disease, Lee BE/Kim HY/Kim HJ/Jeong H/Kim BG/Lee HE/Lee J/Kim HB/Lee SE/Yang YR/Yi EC/Hanover JA/Myung K/Suh PG/Kwon T/Kim JI, (2020.12)
· Science, Aldehyde dehydrogenase 1a1 mediates a GABA synthesis pathway in midbrain dopaminergic neurons, Kim JI/Ganesan S/Luo SX/Wu YW/Park E/Huang EJ/Chen L/Ding JB, (2015.10)