Faculty Research Profile
Jung-Min Kee
학력
· Ph. D. in Organic Chemistry, Stanford University (PI: Paul Wender)
· B.S. KAIST, Korea
주요 경력
· 2014~present : Assistant/Associate Professor, Department of Chemistry, UNIST
· 2008~2014: Postdoctoral Fellow,
The Rockefeller University and Princeton University (PI: Tom Muir)
수상/학회/외부활동
· Samsung Future Technology Foundation (삼성미래기술육성재단) Investigator (2021)
· POSCO Chung-Am Science Fellow (2017)
· President’s Teaching Award, UNIST (2015)
· Damon Runyon Postdoctoral Fellow (2009-2011)
· Eli Lilly Graduate Fellowship (2004-2005)
생유기화학 및 화학생물학 연구실
Bioorganic and Chembio Lab
우리 연구실의 목표는 유기합성화학과 화학생물학(chemical biology)의 도구를 이용하여 복잡한 생물학적 시스템을 분자적 수준에서 이해하는 것입니다. 이를 위해, 저분자 물질, 펩타이드, 합성단백질에 이르는 다양한 새로운 분자 도구를 설계하고 합성하며, 이러한 도구들과 화학단백체학, 단백질 생화학, 의약화학의 방법론을 융합적으로 이용하여, 궁극적으로 차세대 항암제, 항생제 개발의 기반을 마련하고자 합니다. 또한 이를 바이오에너지 생산 및 생체모방 플라스틱 분해 등으로 확장 응용하는 연구 또한 진행중입니다.
As a chemical biology research group, our goal is to understand complex biological systems at the molecular level using tools of synthetic chemistry. For this, we design and synthesize novel molecular tools, ranging from small molecules to peptides and modified proteins, and utilize them in proteomics, protein biochemistry, and drug discovery. We are also expanding our research scope to bioenergy production and plastic degradation.
As a chemical biology research group, our goal is to understand complex biological systems at the molecular level using tools of synthetic chemistry. For this, we design and synthesize novel molecular tools, ranging from small molecules to peptides and modified proteins, and utilize them in proteomics, protein biochemistry, and drug discovery. We are also expanding our research scope to bioenergy production and plastic degradation.
연구분야
화학생물학, 신약개발, 인산화효소, 탈인산화효소, 화학단백체학 / Chemical Biology, Drug Discovery, Kinase, Phosphatase, Chemical Proteomics
Chemical Biology, Drug Discovery, Kinase, Phosphatase, Chemical Proteomics
연구 희망분야
차세대 항생제, 약물저항성, 항암제, 바이오에너지, 플라스틱 분해 / Novel antibiotics, Drug resistance, Anticancer, Bioenergy, Plastic degradation
Novel antibiotics, Drug resistance, Anticancer, Bioenergy
연구주제
- 단백질 인산화/탈인산화효소 기능 연구 / Discovery and characterization of novel protein kinases and phosphatases
- 화학단백체학 / Chemical proteomics
- 신약개발 / Novel antibiotics against drug-resistant bacteria
- 생체모방 플라스틱 분해 / Biomimetic recycling of plastics
- Discovery and characterization of novel protein kinases and phosphatases
- Chemical proteomics
- Novel antibiotics against drug-resistant bacteria
- Biomimetic recycling of plastics
국가연구개발사업 기술 분류체계
국가과학기술표준분류
NC. 화학 > NC02. 유기화학 > NC0207. 생유기화학
논문
Nat. Commun. "Intracristal space proteome mapping using super-resolution proximity labeling with isotope-coded probes" 2025, 16, 7757
Chem. Sci. "Chemoproteomic identification of phosphohistidine acceptors: posttranslational activity regulation of a key glycolytic enzyme" 2025, 16, 8014.
Bioorg. Chem. "A Simple Protein Histidine Kinase Activity Assay for High-throughput Inhibitor Screening" 2023, 130, 106232
Chem. Commun. "Distinct Phosphorylation and Dephosphorylation Dynamics of Protein Arginine Kinases Revealed by Fluorescent Activity Probes" 2019, 55, 7482-7485.
J. Am. Chem. Soc. "A Phosphohistidine Proteomics Strategy Based on Elucidation of a Unique Gas-phase Phosphopeptide Fragmentation Mechanism" 2014, 136, 12899–12911 .
Nature Chem. Biol. “A Pan-specific Antibody for Direct Detection of Protein Histidine Phosphorylation” 2013, 9, 416–421.
특허
PCT/KR2021/015114 "COMPOSITION AND METHOD FOR MEASURING HISTIDINE KINASE ACTIVITY, AND METHOD FOR SCREENING HISTIDINE KINASE INHIBITORS BY USING THE SAME"; filed on Oct 26th, 2021.
U.S. Patent 10,351,581 “Phosphohistidine Mimetics and Antibodies to Same”; issued on July 16th, 2019.
U.S. Patent 9,765,154 “Phosphohistidine Analogs”; issued on September 19th, 2017.
U.S. Patent 8,536,378 “Prostratin and Structural or Functional Analogs Thereof”; issued on September 17, 2013