Faculty Research Profile
Chae Un Kim
학력
2008: Ph. D. Biophysics, Cornell University
1999: B.S. Physics, Seoul National University – Summa Cum Laude (1st place honor in physics)
1995: Korea Science Academy (한국과학영재학교)
주요 경력
2018- Present: Associate Professor,
UNIST
2014-2017: Assistant Professor, UNIST
2009-2014: Staff Scientist, Cornell High
Energy Synchrotron Source (CHESS)
2008: Post.Doc., Cornell High Energy
Synchrotron Source (CHESS)
수상/학회/외부활동
2008: Best PhD Thesis Prize, Cornell High Energy Synchrotron Source
1999: Summa Cum Laude (1st place honor in physics), Seoul National University
고압력 X선 물리연구실
High Pressure X-ray Science Laboratory
우리 실험실에서는 고압과 X-선 기술을 사용하여 생물 및 연성 물질 시스템을 연구합니다. 고압력 극저온 냉각 기법으로 불리는 기술은 생물물리와 X-선 분야에서 고분자 결정의 손상을 방지하기 위해 개발되었습니다. 이 방법은 Ligand-단백질의 상호작용을 안정화하고, 단백질 구조 내부의 압력에 의한 효과를 연구하며, 효소 반응의 중간과정을 포착하는데 성공적으로 적용되었습니다. 우리는 앞으로 고압 냉각 기술을 사용하여 유리질 상태의 물의 상 변화와, 물과 단백질 사이의 상호작용, 그리고 극저온에서의 단백질 구조 및 기능을 연구할 계획입니다.
Our lab studies biological and soft matter systems using high-pressure and X-ray techniques. A high-pressure cryocooling method was developed for crystal cryoprotection in macromolecular crystallography. In addition, the method was successfully applied to stabilize ligand-protein interactions, to study the pressure effect on the structure, and to entrap intermediate enzymatic states. Using the high-pressure method, we will study the phase behaviors of glassy water, water-protein interactions, and protein functions and dynamics at cryogenic temperatures.
Our lab studies biological and soft matter systems using high-pressure and X-ray techniques. A high-pressure cryocooling method was developed for crystal cryoprotection in macromolecular crystallography. In addition, the method was successfully applied to stabilize ligand-protein interactions, to study the pressure effect on the structure, and to entrap intermediate enzymatic states. Using the high-pressure method, we will study the phase behaviors of glassy water, water-protein interactions, and protein functions and dynamics at cryogenic temperatures.
연구분야
X-ray Science, Biophysical Science, Biomedical Science
X-ray Science, Biophysical Science, Biomedical Science
연구 희망분야
단백질 구조와 기능 연구, 고압력 극저온 단백질 결정학 / Protein Structures and Functions, High-Pressure Cryocooling Protein Crystallography
Protein Structures and Functions , High-Pressure Cryocooling Protein Crystallography
연구주제
X-ray Science, Biophysical Science, Biomedical Science:
X-ray Technique Development, Protein Structures and Functions, X-ray Imaging of Biological Assemblies
X-ray Science, Biophysical Science, Biomedical Science:
X-ray Technique Development, Protein Structures and Functions, X-ray Imaging of Biological Assemblies
국가연구개발사업 기술 분류체계
국가과학기술표준분류
NB. 물리학
논문
Nature Communications / Fast product release requires active-site water dynamics in carbonic anhydrase / Kim, Jin Kyun et al. / 2025
Nature Communications / Elucidating the role of metal ions in carbonic anhydrase catalysis / Kim, Jin Kyun et al. / 2020
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals / Kim, Chae Un et al. / 2016
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA / Glass-to-cryogenic-liquid transitions in aqueous solutions suggested by crack healing / Kim, Chae Un; Tate, Mark W.; Gruner, Sol M. / 2015
특허
회전형 동축 광-전자기 도파관 집합체를 포함하는 광음향-초음파 내시경 시스템과 그 구현 방법 / 양준모, 김채운 / US patent 12,383,141 / 2025-08-12
래디얼 어레이 트랜듀서 기반 광음향-초음파 내시경 시스템 / 양준모, 김채운 / US patent 11,660,071 / 2023-05-30